Gray baby syndrome is a condition in which an infant experiences a life-threatening reaction to the antibiotic Chloramphenicol. It is more prevalent in premature infants since an adverse reaction is directly related to the liver’s ability to break down and process the medication.
What causes GREY baby syndrome?
Gray baby syndrome: A syndrome due to toxicity of the antibiotic chloramphenicol in the newborn, especially the premature newborn, because of lack the necessary liver enzymes to metabolize this drug.
How does chloramphenicol cause GREY baby syndrome?
It usually starts 2 to 9 days after treatment is started. The syndrome is a result of chloramphenicol impairing myocardial contractility by directly interfering with myocardial tissue respiration and oxidative phosphorylation.
Why chloramphenicol should not be used in neonates?
In 1958, newborns born prematurely due to rupture of the amniotic sac were given chloramphenicol to prevent possible infections, and it was noticed that these newborns had a higher mortality rate compared with those who were not treated with the antibiotic.
What antibiotics are given to newborns?
The antibiotics that your baby is most likely to be given are amoxycillin and gentamicin. Together these antibiotics are known to work on most types of bacteria that cause an infection. For term babies, amoxycillin is given every 12 hours and gentamicin is given once every 24 hours.
Is Chlorsig safe for newborns?
Some of the symptoms of an allergic reaction to Chlorsig may include irritation, pain and swelling in the eye. Skin rashes, blisters and fever may also occur. Do not give Chlorsig to children under 2 years of age unless your doctor or optometrist tells you.
How does phototherapy reduce bilirubin?
Phototherapy is treatment with a special type of light (not sunlight). It’s sometimes used to treat newborn jaundice by lowering the bilirubin levels in your baby’s blood through a process called photo-oxidation. Photo-oxidation adds oxygen to the bilirubin so it dissolves easily in water.
Which of the following antibiotic is a tetracycline?
Tetracyclines (tetracycline, doxycycline, minocycline, tigecycline) are a class of medication used to manage and treat various bacterial infections. Tetracyclines classify as protein synthesis inhibitor antibiotics and are considered to be broad-spectrum.
What generation is Keflex?
Some first-generation cephalosporins are used as prophylactic antibiotics for surgery involving the chest, abdomen, or pelvis. Examples of first-generation cephalosporins include: cephalexin (Keflex)
Which class of antibiotic is streptomycin?
Streptomycin belongs to a class of drugs known as aminoglycoside antibiotics. It works by killing the organisms that cause the infection. This drug may also be used to treat other serious infections (e.g., Mycobacterium avium complex-MAC, tularemia, endocarditis, plague) along with other medications.